Welcome to the Reproductive Endocrinology Unit
1978
Established a nationally & internationally famous training program for physicians & basic scientists in research in human reproduction
1980
Developed pulsatile GnRH treatment to induce ovulation in infertile women
1981
Demonstrated therapeutic use of long acting GnRH agonist treatment for children with precocious puberty
1982
Pioneered GnRH pump treatment to induce puberty in hypogonadotropic males and demonstrated their nearly uniform GnRH Deficiency
1983
Reproductive Endocrine Unit established
1983
Reproductive Endocrine Associates Group Practice established in the REU
1983
Demonstrated long term therapeutic use of long acting GnRH agonist treatment for children with precocious puberty
1986
First reported optimization of ovulation induction with pulsatile GnRH
1988
Obtained FDA approval for GnRH agonist in precocious puberty
1988
Demonstrated hypothalamic defects in women with amenorrhea and PCOS
1992
Described first LHβ mutation causing hypogonadotropic hypogonadism
1992
Obtained FDA approval of ovulation induction with pulsatile GnRH
1993
First comparison of pulsatile GnRH vs exogenous gonadotropin therapy to reduce multiple gestations
1994
Established the efficacy of pulsatile GnRH treatment for women with central nervous system radiation
1994
Obtained patents on Vaginal ring contraception delivery system developed in collaboration with Dr. Robert Langer of MIT
1994
First quantified the staggering economic impact of multiple gestations related to ovulation induction with exogenous gonadotropins
1996
Elucidated the role of estrogen replacement on folliculogenesis in women with premature ovarian insufficiency
1997
Described adult-onset hypogonadotropic hypogonadism: a treatable form of male infertility
1999
Reproductive Endocrine Associates Group Practice celebrated for research/innovation/practice interface
2003
Discovered new gene (Kisspeptin Receptor) that controls puberty in humans
2004
REU faculty member Dr. Seminara received Presidential Early Career Award for Scientists and Engineers, awarded at the White House
2005
Demonstrated reversibility of Kallmann Syndrome
2006
Demonstration that mutations in FGFR1 cause normosmic isolated GnRH Deficiency
2006
Change to “Demonstrated kisspeptin induced desensitization of GnRH secretion
2007
First description of PROK2 mutations causing Kallmann syndrome
2007
First prospective documentation of 'reversible Kallmann Syndrome and normosmic hypogonadotropism
2009
Demonstrated Kisspeptin-independent GnRH secretion in kiss1 and kiss1r knockout mice
2009
Description of mutations in GnRH1 in Isolated GnRH Deficiency
2010
Demonstrated that more than one gene is often involved in causing Kallmann Syndrome and Idiopathic Hypogonadotropism
2010
Description of TACR3 mutations characterized by early developmental defects followed by late reversals
2011
Description of genetic defects in women with hypothalamic amenorrhea
2011
Demonstrated that kisspeptin resets the hypothalamic GnRH clock in men
2011
Described of mutations in Heparan sulfate 6-O-sulfotransferase I causing human GnRH Deficiency
2012
Described a 9,000 year old founder mutations in PROKR2 causing isolated GNRH Deficiency
2013
Discovery of genetic defects in ubiquitin pathway genes in patients with a neurodegenerative disorder including hypogonadism and ataxia
2013
Described mutations in the FGF synexpression group in human GnRH deficiency
2014
Described functionally deleterious CHD7 mutations in human GnRH deficiency
2015
Described multiple founder alleles causing human GnRH deficiency
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Mission Statement

To provide a broad-based clinical and basic investigational program into the scientific basis of reproductive disorders in men, women and children.

To translate these findings rapidly into state-of-the-art care for our patients.

To train other biomedical research professionals how to do this and establish independent research careers in reproduction and clinical investigation.

To mentor women and minorities interested in pursuing academic careers in reproduction.

To administer the Biomedical Research Career Award (BMRCA) mentoring and didactic program for emerging scientists to enable their participation during the critically formative years.


home-reproductive-endocrinology-clinical-servicesClinical Services

We provide the highest quality reproductive medical care to both men and women. MORE + 

home-reproductive-endocrinology-research-programsResearch Programs

Our program provides its trainees with an intensive research experience under the attentive mentorship of a skilled faculty. MORE +

 

home-reproductive-endocrinology-training-programsTraining & Programs

The REU has been highly effective in obtaining grants from the National Institutes of Health for its cutting edge research. MORE +

 

home-reproductive-endocrinology-research-participationInterested in Participating in Research?

Several outpatient and inpatient studies are currently underway.  MORE +

 

Make an Appointment

We offer two locations for our services. Our Physician Practice, Reproductive Endocrine Associates is located in the Wang Building, and our Ultrasound and Research Clinic is located in the Bartlett Hall Extension. Both locations are part of the Wang Pavilion, adjacent to the Bulfinch Lawn off of Parkman Street. MORE +


Contact Us

Reproductive Endocrine Associates / REU Ultrasound Clinic
55 Fruit Street, BHX-4
Boston, MA 02114-2696

Phone: (617) 726-8433
Fax: (617) 726-5357
Email: MGHReproEndoAssociates@partners.org

REPRODUCTIVE ENDOCRINE ASSOCIATES
Location: Wang Building, 7th Floor
Hours of Operation
Monday: 8:30am – 5:00pm
Thursday: 8:30am – 5:00pm
Friday: 8:30am – 5:00pm

REU ULTRASOUND & RESEARCH CLINIC
Location: Bartlett Hall Extension, 4th Floor
Hours of Operation:
Monday – Friday: 8:30am – 5:00pm