The Reproductive Endocrine Unit is proud of its long-standing history of training the next-generation of physician-scientists and basic scientists in reproductive biology. The REU’s training environment is highly interactive and this collaborative spirit is witnessed during weekly research conferences, clinical conferences and team meetings. The emphasis on training is one of the key factors that has helped establish the strong links between our clinical, teaching and research missions—facilitating the best patient care and support of developing investigators.
Current Research Trainees: Michelle (Wanxue) Xu
Uniting Science and Clinical Care
The Reproductive Endocrine Unit at Mass General leads broad-based clinical and basic research programs into the scientific basis of reproductive disorders. In addition to educating the next generation of reproductive endocrinologists, we seek to translate our clinical findings into top-quality, state-of-the-art care for patients with reproductive disorders.
REU Clinical Conference Series
Meets every Thursday to review and discuss interesting cases.
Eliot B. Shoolman Lecture Series
Renowned Scientists are invited to lecture on the latest research findings and techniques. Every other Tuesday, with a break in the summer months to accommodate academic vacation calendar.
Endocrine Grand Rounds
Meets every Tuesday, the entire division comes together and discusses cases from all Endocrine specialties.
Meets Every Wednesday to review current articles published, in press and to be published.
Department of Medicine Grand Rounds
Meetings every Thursday morning.
The Reproductive Endocrine Unit (REU) at Massachusetts General Hospital has an impressive tradition of training physician-scientists in reproductive biology. Since its inception in 1980, the REU has trained 54 fellows: 43 currently hold academic medical positions (25 with tenure) and 6 hold senior positions in the biotechnology/pharmaceutical industry. From a scientific perspective, during the past 3 decades, the REU has pioneered:
1) the use of pulsatile GnRH to induce puberty in males and ovulation induction in females,
2) the use of GnRH agonists to treat precocious puberty,
3) the elucidation of hypothalamic defects in women with hypothalamic amenorrhea and polycystic ovary syndrome,
4) the description of acquired hypogonadotropism, and
5) the discovery of genes that control sexual maturation in the human.
The Reproductive & Developmental Biology Training Program at the Massachusetts General Hospital provides its trainees with an intensive research experience in basic and/or clinical investigation under the attentive mentorship of a skilled faculty member and complemented by a strong didactic program underpinning the sciences of reproductive and developmental biology. Trainees are selected from a highly talented applicant pool of M.D.’s, M.D./Ph.D.’s, or Ph.D.’s on the basis of their prior academic and/or research accomplishments, a strong future commitment to an academic career in biomedical investigation, and a personal interview indicating their proper motivation and future potential.
The PI (Dr. William Crowley) is a Professor of Medicine at Harvard Medical School and the Director of two NIH-funded Centers. He is an established senior scientist and recognized mentor who shares the governance of this program with the Unit Chief (Dr. Stephanie Seminara) who serves as Co-Director. The total training faculty consists of 13 active, well-funded scientists whose diverse expertise and investigative interests line a spectrum of reproductive and developmental research from fundamental developmental biology to bench-to-bedside translational clinical investigations.
The T32 Training Program in Reproduction provides training and career development for the most competitive post-doctoral candidates committed to independent academic careers. The T32 offers several opportunities embedded within investigative centers across Harvard. In addition to The Reproductive Endocrine Unit, faculty for the T32 are situated within The Analytical and Translational Genetics Units (Department of Medicine, MGH), the Center for Human Genetic Research (MGH), and the Broad Institute (Harvard/MIT). This broad-based environment offers rich exposure to cutting edge science.
Trainees are closely supervised by an active and individualized mentorship program overseen by the senior faculty and are encouraged to interact extensively with junior faculty who typically serve as in a co-mentorship role. An extensive program of rigorous didactic sessions interlaces tightly with individually strong, independent laboratory programs that remain at the heart of the trainees’ program and complements their 2-3 years of research experience. Typically, the training period involves several additional years as junior faculty that permits the consolidation of skills required for maximal competitiveness for subsequent independent support, the ultimate goal of their training program.
Biomedical Research Career Award
Appropriate for college students, recent graduates, or medical students interested in biomedical research careers, the Biomedical Research Career Award Program (BMRCA) offers students a combined mentored research experience and educational program in clinical investigation within a group of world-class clinical researchers in human reproduction.
The Biomedical Research Career Award Program (BMRCA) is typically 12 months in duration but on occasion may last a second year when a project’s pace dictates. It may occur in the middle of college, between college and medical school, or during medical school. Since this is not a strict employment situation but rather an educational experience, no salary will be paid. However, stipends may be provided depending on the availability of resources and the chosen research project.
It is our experience that the educational experience is significantly diluted if students take other course work outside of Mass General. However, there may be specific instances in which courses in statistics or other research techniques may be appropriate. There is no additional stipend to support the tuition for any such courses. Course enrollment must be discussed in advance with the mentor, and time away from the lab during key working hours must be a serious consideration.
The Reproductive Endocrine Unit invites motivated students seeking to explore research and medicine to join us during the summer to participate and experience a research unit. They will attend several of the weekly didactic meetings and be mentored by junior faculty and Fellows in areas of reproductive medicine.
Due to the high volume of interest in this program, incomplete applications will not be considered. Please be sure to apply when you have all of the components of the application ready. This includes:
– 2 letters of reference should be emailed to MGHReproductiveEndocrine@partners.org
– current transcript with GPA
– Personal Statement of why this research interests you and how your experience will assist you in planning your career