The overall goal of Dr. Crowley’s laboratory over the past 25 years has been to improve the understanding and treatment of reproductive disorders affecting humans. Dr. Crowley’s team have focused on gaining insights into the neuroendocrine and genetic control of GnRH secretion, its impact upon gonadotropin secretion and gonadal physiology as well as it regulation by higher neural regulation. These critical insights into the control of reproduction have been made possible by studying human diseases where puberty is completely absent (e.g. Kallmann Syndrome and idiopathic hypogonadotropic hypogonadism). Dr. Crowley heads the Novel Gene Discovery efforts through the “Genetics Study” which involves recruitment of patients with Kallmann Syndrome and related disorders, recruitment of their families, as well as recruitment of patients and families with common reproductive disorders such as delayed puberty and hypothalamic amenorrhea. These studies have begun to uncover several new genes that control normal human reproduction. This genetics study builds on the information already obtained from the Human Genome Project and in addition, incorporates biochemical, cellular, genetic and animal approaches wherever appropriate.