Research Studies

On this page is a list of all Reproductive Endocrine studies currently recruiting study participants, along with basic qualifications for participating:


Title: The Molecular Basis of Inherited Reproductive Disorders (Kallmann Syndrome)
PI: William F. Crowley
Synopsis: The purpose of this study is to learn about the hereditary basis of disorders of the reproductive system including early puberty, late puberty, complete absence of puberty, and typical puberty that is accompanied by abnormalities of the reproductive system later in life.



Title: The Role of Gonadotropin Pulsations In Reversal Of Hypogonadotropic Hypogonadism
PI: William F. Crowley
Synopsis: The purpose of study is 1) identify men, women and adolescent boys with disorders of GnRH secretion; 2) describe the spectrum of reproductive disorders; and 3) to study the physiology and control of the reproductive system in the human.



Title: Psychology, Behavior and Sex Hormones Study
PI: William F. Crowley
Synopsis: The purpose of this study is to evaluate the role of pubertal exposure of sex hormones on behavior and psychology in humans.




In our kisspeptin studies, we are trying to understand how the brain controls the timing of puberty and the maintenance of normal fertility throughout our lives.  To do this, we administer a brain hormone called kisspeptin. Kisspeptin is critical for normal reproduction and is made in very high levels during pregnancy. It is a key driver for several other reproductive hormones that are also made in the brain and pituitary gland (see next paragraph).  These hormones ultimately bring about the production of testosterone and sperm in men, and estrogen and eggs in women.  Kisspeptin is not available for clinical use and can only be used in research studies.

During many of these studies, we also administer another naturally occurring brain hormone called GnRH (short for “gonadotropin-releasing hormone”). GnRH is the next hormone downstream from kisspeptin.  In other words, kisspeptin stimulates GnRH and GnRH stimulates the pituitary gland to produce additional hormones (gonadotropins) for normal reproductive function. It is very helpful for our team to compare the response to GnRH and kisspeptin side by side. 

Title: Kisspeptin Physiology in the Human
PI: Dr. Seminara
Synopsis: The goal of this research study is to understand how kisspeptin works as a gatekeeper of reproductive hormone secretion in the brain. Participants will receive both kisspeptin and GnRH. We are looking for healthy subjects and subjects with reproductive disorders. 

Study participation involves 2 clinic visits and 1 or 2 hospital visits (3-15 hours each, starting in the morning and ending in the evening). Participants will be compensated up to $660. Individuals interested in learning more may contact the Massachusetts General Hospital Kisspeptin Research Team at 617-724-8764 or the email below.