Dr. Maria Stamou

Dr. Maria’s Stamou deep interest in biomedical research and genetics goes back to her medical school years at the University of Patras, Greece where she graduated as an outstanding student in 2011. As a reflection of her passion and thorough understanding of the particular science and medical knowledge she has been awarded from the State Scholarships’ Foundation of Greece as the year’s best student for the academic years 2006-2009 and she was successfully accepted as a PhD graduate student in the Clinical and Laboratory Translational Postgraduate Program, Department of Endocrinology, University of Patras School of Medicine. Under the supervision of Dr. N. Georgopoulos she was trained in the genetics of Isolated GnRH deficiency (IGD) learning techniques of genomic sequencing and functional validation.

Based on her strong future commitment to an academic career in biomedical investigation, she was accepted as a Research Fellow in the highly competitive Reproductive Endocrinology Training program of Massachusetts General Hospital, where she trained under the supervision of Dr. William F. Crowley and Dr. Balasubramanian Ravikumar. Maria has a strong interest in research concerning the biology of GnRH (Gonadotropin Releasing Hormone), the large spectrum of different reproductive phenotypes in humans with Isolated GnRH deficiency with anosmia (Kallmann syndrome), and all of its clinical variants. She is focusing on analyzing the complicated phenotype of Isolated GnRH Deficiency and it’s correlation to genetics.

The ultimate goal of her studies is to determine the genetic causes of IGD in both familial and sporadic cases with IGD by utilizing next-generation sequencing techniques as well as in IGD individuals with complex structural variations by using novel techniques such as the jumping libraries based whole genome sequencing. In collaboration with Dr. Michael Talkowski, Center of Human Genetic Research, MGH, Boston, Maria has developed a detailed and complete approach of analyzing such specific chromosomal breaks with the ultimate goal of hers being to identify the underlying mechanism of the chromosomal abnormalities as well as their clinical significance in a human disease model such as the isolated GnRH deficiency. By the end of her training she will be able to receive a deep understanding of the role that genetic alterations play in the variable expression of IGD.