Reproductive Endocrinology Clinical Services

Clinical Services

The Reproductive Endocrine Associates Group Practice was established to provide the highest quality reproductive medical care for both men and women, while providing our patients the benefits of the most recent translation of our scientific and technological advances resulting from the ongoing basic and clinical investigations within our Unit. Examples of such novel therapies, derived from our research program and now available in this practice, includes pulsatile GnRH for induction of puberty and ovulation and the use of potent GnRH agonists for the treatment of precocious puberty, both of which have now been FDA approved on the basis of studies performed in our Unit.

Reproductive Endocrine Associates

Teaching Role

The Reproductive Endocrine Associates serves as a platform for training Endocrine Fellows and MGH housestaff and Harvard Medical Students rotating through the Clinical Endocrinology Service. Fellows and residents see patients under the supervision of our Harvard faculty, and participate in all longitudinal care, including ovulation induction.

REU Mass General

Ovulation Induction

Our practice offers a comprehensive program of ovulation induction with on-site transvaginal ultrasound and rapid serum estradiol monitoring during the administration of clomiphene citrate, human recombinant FSH, and pulsatile GnRH. We have the world’s largest clinical experiences using pulsatile GnRH for anovulatory infertility and continue to serve as a major referral site for this therapy, nationally and internationally. Through the National Center for Infertility Research, we continue to develop novel clinical protocols to improve both ovulatory and conception rates for anovulatory patients, but also to pursue both physiologic investigation of the normal menstrual cycle and the genetic basis of reproductive disorders.

We also have extensive experience with exogenous gonadotropins, both human menopausal and more recently, recombinant gonadotropins, and have the lowest reported rate of multiple gestation when compared to other large series in the literature (Martin 1993). The economic impact of multiple gestations has also been studied by our Unit (Callahan), and emphasizes the critical importance of minimizing multiple gestation rates, both for patient safety and reduction of health care costs.

In addition, the REU has pioneered the use of pulsatile GnRH for induction of puberty and spermatogenesis in men with GnRH deficiency. While ongoing research projects are extremely important, patient care and quality physician-patient relationships are our highest priorities. The success and uniqueness of the Reproductive Endocrine Unit’s practice was recently highlighted by an invitation to publish it as a model of an academic/clinical investigative practice in the Journal of Clinical Endocrinology and Metabolism.

 Reproductive Endocrine Research and Ultrasound Clinic

Judith Adams RNJudith Adams, RN, DMU, RDMS, an internationally recognized expert in pelvic ultrasonography, has been staff ultrasonographer with the Reproductive Endocrine Associates since 1987. In addition to playing a critical role in our ovulation induction program, she has an active role in many ongoing research protocols.

Since 2004, the Reproductive Endocrine Associates practice has been accredited by the American Institute of Ultrasound in Medicine (AIUM) in recognition of its excellence in patient care.

 

 

Interface with Clinical Investigation

The Reproductive Endocrine Associates practice is directed by Dr. Frances Hayes, our Associate Chief for Clinical and Teaching Affairs.  It consists of eight adult endocrinologists, all of whom have expertise in clinical investigation as well as practice. We provide comprehensive specialty services for patients with reproductive endocrine problems–including menstrual cycle abnormalities, polycystic ovarian syndrome, menopause and hormone replacement therapy, male and female infertility, premature ovarian failure, Kallmann’s Syndrome, and pubertal disorders. Services are also available for a wide spectrum of reproductive disorders not included in this list. In addition, as part of the National Center for Infertility Research, ongoing clinical and basic research projects within the Unit continuously provide new information on these disorders, providing patients with access to new and innovative clinical investigation protocols.

 

 

REU-SigDiff-chart

Diagnosis and Treatment

REU Both Male and Female

Both Male and Female

Conditions covered for both male and female patients:

– Delayed Puberty
– Normosmic Idiopathic Hypogonadotropic Hypogonadism (IHH) / Kallmann Syndrome (KS)

reu-diagnostic-female

Female

Conditions covered for female patients:

– Polycystic Ovary Syndrome (PCOS)
– Menopause
– Premature Ovarian Insufficiency (POI)
– Hypothalamic Amenorrhea

research-male-team

Male

Conditions covered for male patients:

– Male hypogonadism (Low Testosterone)
– Gynecomastia
– Erectile Dysfunction

Physicians

Reproductive Endocrine Associates Physicians

Ravikumar Balasubramanian, MBBS, MRCP, PhD
William Crowley, MD
Janet Hall, MD
Frances Hayes, MD
Margaret Lippincott, MD
Kathryn Martin, MD
Stephanie Seminara, MD 

 

Ravi Balasubramanian MD PhD

Dr. Ravikumar Balasubramanian

Title: Assistant in Medicine, Massachusetts General Hospital; Assistant Professor of Medicine, Harvard Medical School; Director, Research Education – REU
Medical School: Dr. MGR Medical University, Madras, India
Royal College of Physicians, Edinburgh, UK
Residency: Royal Bolton & Royal Preston Hospital, Internal Medicine
Fellowship: Yorkshire Deanery, Diabetes & Endocrinology
Addenbrooke’s Hospital, University of Cambridge, Diabetes & Endocrinology Newcastle University, Diabetes & Endocrinology
Massachusetts General Hospital, Reproductive Endocrinology
Research Interests: GnRH Deficiency

 

William Crowley MD

Dr. William F. Crowley

Title: Chief, Reproductive Endocrine Unit ; Daniel K. Podolsky Professor of Medicine, Harvard Medical School; Director, Harvard Reproductive Endocrine Sciences Center
Medical School: Tufts Medical School
Residency: Massachusetts General Hospital, Internal Medicine
Fellowship: Massachusetts General Hospital, Endocrinology
Research Interests: Kallman’s Syndrome, GnRH Deficiency

 

Janet Hall MD

Dr. Janet Hall

Title: Clinical Director, National Institute of Environmental Health Sciences – NIH; Clinical Affiliate, Massachusetts General Hospital; Professor of Medicine, Harvard Medical School on Sabbatical
Medical School: McMaster University, Canada
Residency: McMaster University, Internal Medicine
Fellowship: Massachusetts General Hospital, Endocrinology

 

Frances Hayes

Dr. Frances J. Hayes

Title: Associate Chief of Clinic and Education, Reproductive Endocrine Unit; Associate Professor of Medicine, Harvard Medical School; Division Clinic Director, Endocrine Division; Clinical Director, Reproductive Endocrine Associates and REU Ultrasound Clinic;  Medical Director, MGH Abbott Center of Excellence;  Co-Director, Turner Syndrome Clinic at MGH
Medical School: University College of Dublin, Ireland
Residency: St. James’ Hospital in Dublin, Internal Medicine
Fellowship: St. Vincent’s Hospital in Dublin, Endocrinology Massachusetts General Hospital, Reproductive Endocrinology

 

Margaret Lippincott MD

Dr. Margaret Lippincott

Title: Assistant in Medicine, Massachusetts General Hospital
Instructor, Harvard Medical School
Medical School: Duke University Medical School
Residency: Beth Israel Deaconess Medical Center, Internal Medicine
Fellowship: Massachusetts General Hospital, Endocrinology
Research Interests: Kisspeptin and GnRH Deficiency

 

Kathrn Martin MD

Dr. Kathryn Martin

Title: Assistant in Medicine, Massachusetts General Hospital; Assistant Professor of Medicine, Harvard Medical School; Senior Deputy Editor, UptoDate / Wolters Kluwer Health
Medical School: Dartmouth Medical School, Harvard University
Residency: Emory University Affiliated Hospital, Internal Medicine
Fellowship: Massachusetts General Hospital, Endocrinology and Metabolism

  

Stephaniw Seminara MD

Dr. Stephanie B. Seminara

Title: Associate Chief of Research and Administration, Reproductive Endocrine Unit; Professor of Medicine, Harvard Medical School; Co-Director, Harvard Reproductive Endocrine Sciences Center
Medical School: Harvard Medical School, Harvard University
Residency: Massachusetts General Hospital, Internal Medicine
Fellowship: Massachusetts General Hospital, Reproductive Endocrinology
Research Interests: Kisspeptin