Dr. Janet Hall

Dr. Hall is Professor of Medicine at Harvard Medical School, Associate Physician in Medicine at the Massachusetts General Hospital, Associate Chief of the Reproductive Endocrine Unit and a recent President of the Endocrine Society.

Dr. Hall’s studies have provided increasing evidence that in women, in addition to the effects of ovarian aging, there are dramatic hypothalamic and pituitary changes, which occur with aging in women and may contribute She is currently investigating the impact of aging on cognitive responses to estrogen replacement using a combination of neuroimaging techniques. In collaborative studies she is also using neuroimaging studies to understand the relationship between hot flashes, sleep and depression in postmenopausal women and women using estrogen deprivation therapy.

Dr. Hall has a longstanding interest in patients with idiopathic hypogonadotropic hypogonadism. She was intimately involved in studies leading to FDA approval of pulsatile GnRH for treatment of relative or complete GnRH deficiency. Conception rates are high in patients with hypogonadotropic hypogonadism, while the risks of multiple gestation and hyperstimulation are lower than with alternative therapies. The importance of controlling the risk of multiple gestation is emphasized in studies in which she has demonstrated the profound economic and social impacts of this complication of ovulation induction. Collaborations with others in the MGH Reproductive Endocrine Unit have resulted in dramatic progress in understanding the genetic underpinnings of this disorder that involve not only signals governing the migration of GnRH neurons to the hypothalamus, but also upstream regulation of GnRH in the hypothalamus .

A recipient of the A. Clifford Barger Excellence in Mentoring Award from Harvard Medical School, Dr. Hall is a clinical investigator who is actively involved in training students, fellows and young investigators. Her work is supported by R01 grants from the NIH and previously by a Midcareer Award in Patient-Oriented Research from the NIH. In addition, she has an active clinical practice with a particular interest in menstrual cycle abnormalities (such as polycystic ovarian syndrome, premature menopause, hypothalamic amenorrhea), as well as infertility and menopause. She has extensive experience with the use of clomiphene, gonadotropins and pulsatile GnRH for ovulation induction in women with anovulatory disorders and unexplained infertility.

Selected Publications:

• Shaw ND, Srouji SS, Histed SN, Hall JE. Differential effects of aging on estrogen negative and positive feedback. Am J Physiol Endocrinol Metab 2011 Aug 301(2):E351-5. Epub 2011 May 10 PMID: 21558550.

• Shaw ND, Klingman KM, Srouji SS, Histed SN, Hall JE. Gonadotropin responses to estrogen negative and positive feedback are identical in African-American and Caucasian women. J Clin Endocrinol Metab. 2012 Jan;97(1):E106-9. Epub 2011 Nov 2. PMID:22049179.

• Joffe H, Deckersbach T, Lin NU, Makris N, Skaar TC, Rauch SL, Dougherty DD, Hall JE. Metabolic activity in the insular cortex and hypothalamus predicts hot flashes: an FDG-PET study. J Clin Endo

• Shaw ND, Butler JP, McKinney SM, Nelson SA, Ellenbogen JM, Hall JE. Insights into puberty: the relationship between sleep stages and pulsatile LH secretion. J Clin Endocrinol Metab. 2012 Nov; 97(11): E2055-62.doi: 10.1210/jc2012-2692. Epub 2012 Sept 4 PMID: 22948756.

• Abel BS, Shaw ND, Brown JM, Adams JM, Alati T, Martin KA, Pitteloud N, Seminara SB, Plummer L, Pignatelli D, Crowley WF Jr, Welt CK, Hall JE. Responsiveness to a physiologic regimen of GnRH therapy and relation to genotype in women with isolated hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2013 Feb;98(2):E206-16.doi:10.1210/jc.2012-3294. Epub 2013 Jan 22. PMID: 23341491.

• Joffe H, White DP, Crawford SL, McCurnin KE, Economou N, Connors S, Hall JE. Adverse effects of induced hot flashes on objectively recorded and subjectively reported sleep: results of a gonadotropin-releasing hormone agonist experimental protocol. Menopause 2013 Sept; 20(9):905-14. PMID: 23481119.

• Margolin DH, Kousi M, Chan YM, Lim ET, Schmahmann JD, Hadjivassiliou M, Hall JE, Adam I, Dwyer A, Plummer L, Aldrin SV, O’Rourke J, Kirby A, Laage K, Milunsky A, Milunsky JM, Chan J, Hedley-Whyte ET, Daly MJ, Katsanis N, Seminara SB. Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination. N Engl J Med. 2013 May 23;368(21):1992-2003 [Epub 213 May8]. PMID: 23656588.

• Shaw ND, Goodwin JL, Silva GE, Hall JE, Quan SF, Malhotra A. Obstructive sleep apnea (OSA) in preadolescent girls is associated with delayed breast development compared to girls without OSA. J Clin Sleep Med 2013;Aug 15 9(8):813-818. PMID: 23946712

• Shaw N, Srouji S, Welt C, Cox K, Fox J, Adams J, Sluss P, Hall J. Evidence that increased ovarian aromatase activity and expression account for higher estradiol levels in African American compared with Caucasian women. J Clin Encdocrinol Metab 2013 Nov17 [Epub ahead of print] PMID: 24285681.

• Joffe H, Crawford S, Economou N, Kim S, Regan S, Hall JE,* White DP.* A gonadotropin-releasing hormone agonist model demonstrates that nocturnal hot flashes interrupt objective sleep. Sleep 2013 Dec1;36 (12):1977-85. PMID: 24293774