Reproductive Endocrinology Associates

Reproductive Endocrine Associates

Teaching Role

The Reproductive Endocrine Associates serves as a platform for training Endocrine Fellows and MGH housestaff and Harvard Medical Students rotating through the Clinical Endocrinology Service. Fellows and residents see patients under the supervision of our Harvard faculty, and participate in all longitudinal care, including ovulation induction.

REU Mass General

Ovulation Induction

Our practice offers a comprehensive program of ovulation induction with on-site transvaginal ultrasound and rapid serum estradiol monitoring during the administration of clomiphene citrate, human recombinant FSH, and pulsatile GnRH. We have the world’s largest clinical experiences using pulsatile GnRH for anovulatory infertility and continue to serve as a major referral site for this therapy, nationally and internationally. Through the National Center for Infertility Research, we continue to develop novel clinical protocols to improve both ovulatory and conception rates for anovulatory patients, but also to pursue both physiologic investigation of the normal menstrual cycle and the genetic basis of reproductive disorders.

We also have extensive experience with exogenous gonadotropins, both human menopausal and more recently, recombinant gonadotropins, and have the lowest reported rate of multiple gestation when compared to other large series in the literature (Martin 1993). The economic impact of multiple gestations has also been studied by our Unit (Callahan), and emphasizes the critical importance of minimizing multiple gestation rates, both for patient safety and reduction of health care costs.

In addition, the REU has pioneered the use of pulsatile GnRH for induction of puberty and spermatogenesis in men with GnRH deficiency. While ongoing research projects are extremely important, patient care and quality physician-patient relationships are our highest priorities. The success and uniqueness of the Reproductive Endocrine Unit’s practice was recently highlighted by an invitation to publish it as a model of an academic/clinical investigative practice in the Journal of Clinical Endocrinology and Metabolism.